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発表論文_大西 利幸


Takeuchi, J.; Okamoto, M.; Akiyama, T.; Muto, T.; Yajima, S.; Sue, M.; Seo, M.; Kanno, Y.; Kamo, T.; Endo, A.; Nambara, E.; Hirai, N.; Ohnishi, T.; Cutler, S. R.; Todoroki, Y.: Designed abscisic acid analogues as antagonists of PYL-PP2C receptor interactions, Nat. Chem. Biol. 2014, in press.
Murata, A.; Akaike, R.; Kawahashi, T.; Tsuchiya, R.; Takemoto, H.; Ohnishi, T.; Todoroki, Y.; Mase, N.; Yokoyama, M.; Takagi, K.; Winterhalter, P.; Watanabe, N.: Characterization of flower-inducing compound in Lemna paucicostata exposed to drought stress, Tetrahedron 2014, in press.
Keeling, C.; Henderson, H.; Li, M.; Dullat, H.; Ohnishi, T.; Bohlmann, J.: CYP345E2, an antenna-specific cytochrome P450 from the mountain pine beetle, Dendroctonus ponderosae Hopkins, catalyses the oxidation of pine host monoterpene volatiles, Insect. Biochem. Mol. Biol. 2013, 43, 1142-1151.
Koeduka, T.; Suzuki, S.; Iijima, Y.; Ohnishi, T.; Suzuki, H.; Watanabe, B.; Shibata, D.; Umezawa, T.; Pichersky, E.; Hiratake, J.: Enhancement of production of eugenol and its glycosides in transgenic aspen plants via genetic engineering, Biochem. Biophys. Res. Commun. 2013, 436, 73-78.
Magome H., Nomura T., Hanada A., Takeda-Kamiya N., Ohnishi T., Shinma Y., Katsumata T., Kawaide H., Kamiya Y., Yamaguchi S.: CYP714B1 and CYP714B2 encode gibberellin 13-oxidases that reduce gibberellin activity in rice, Proc. Natl. Acad. Sci. USA 2013, 110, 1947-1952.
Ohnishi T., Godza B., Watanabe B., Fujioka S., Hategan L., Ide K., Shibata K., Yokota T., Szekeres M., Mizutani M.: CYP90A1/CPD, a Brassinosteroid Biosynthetic Cytochrome P450 of Arabidopsis, Catalyzes C-3 Oxidation, J. Biol. Chem. 2012, 287, 31551-31560.
Sakamoto T., Ohnishi T., Fujioka S., Watanabe B., Mizutani M.: Rice CYP90D2 and CYP90D3 catalyze C-23 hydroxylation of brassinosteroids in vitro, Plant Physiol. Biochem. 2012, 58, 220-226.
Hirata H.#, Ohnishi T.#, Ishida H., Tomida K., Sakai M., Hara M., Watanabe N.: Functional characterization of aromatic amino acid aminotransferase involved in 2-phenylethanol biosynthesis in isolated rose petal protoplasts, J. Plant Physiol. 2012, 169, 444-451. (# equally contribution)
Okazaki M., Kittikorn M., Ueno K., Mizutani M., Hirai N., Kondo S., Ohnishi T., Todoroki Y.: Abscinazole-E2B, a practical and selective inhibitor of ABA 8'-hydroxylase CYP707A, Bioorg. Med. Chem. 2012, 20, 3162-3172.
Todoroki Y., Naiki K., Muramatsu T., Ohnishi T., Ueno K., Mizutani M., Hirai N.: A conformationally restricted uniconazole analogue as a specific inhibitor of rice ent-kaurene oxidase, CYP701A6, Bioorg. Med. Chem. Lett. 2012, 22, 3240-3243.
平田拓, 大西利幸, 渡辺修治: 香りの生合成経路が季節によって変わる, 化学と生物 2012, 50, 570-576.
大西利幸: 針葉樹の化学防御物質ジテルペン樹脂酸の生合成, バイオサイエンスとインダストリー 2012, 70, 365-369.
肥塚崇男, 大西利幸, 松井健二: 植物をもっとグリーンにする~環境負荷を与える揮発性化合物の抑制, AROMA RESEARCH 2012, 52, 302-307.
Hamberger B.#, Ohnishi T.#, Hamberger B., SeguinA., Bohlmann J.: Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects, Plant Physiol. 2011, 157, 1677-1695. (# equally contribution)
Seki H., Sawai S., Ohyama K., Mizutani M., Ohnishi T., Sudo H., Fukushima EO., Akashi T., Aoki T., Saito K., Muranaka T.: Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin, Plant Cell 2011, 23, 4112-4123.
Okazaki M., Nimitkeatkai H., Muramatsu T., Aoyama H., Ueno K., Mizutani M., Hirai N., Kondo S., Ohnishi T., Todoroki Y.: Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8'-hydroxylase CYP707A, Bioorg. Med. Chem. 2011, 19, 406-413.
Todoroki Y., Narita K., Muramatsu T., Shimomura H., Ohnishi T., Mizutani M., Ueno K., Hirai N: Synthesis and biological activity of amino acid conjugates of abscisic acid, Bioorg. Med. Chem. 2011, 19, 1743-1750.
Dong F., Yang Z., Baldermann S., Kajitani Y., Ota S., Kasuga H., Imazeki Y., Ohnishi T., Watanabe N.: Characterization of L-phenylalanine metabolism to acetophenone and 1-phenylethanol in the flowers of Camellia sinensis using stable isotope labeling, J. Plant Physiol. 2011, 169, 217-225.
Chen XM, Kobayashi H., Sakai M., Hirata H., Asai T., Ohnishi T., Watanabe N.: Functional characterization of rose phenylacetaldehyde reductase (PAR), an enzyme involved in the biosynthesis of the scent compound 2-phenylethanol, J. Plant Physiol. 2011, 168, 88-95.
有村源一郎, 大西利幸: 植物由来のテルペンを介したEcological volatiles その分子基盤, 植物の生長調節 2011, 46, 58-67.
大西 利幸, 水谷 正治: シトクロムP450の酵素化学から導き出された新規ブラシノステロイド生合成経路, 植物のシグナル伝達 分子と応答 2010, 15-22.
Ohnishi T., Yokota T., Mizutani M.: Insights into the function and evolution of P450s in plant steroid metabolism, Phytochemistry 2009, 70, 1918-1929.
Seki H., Ohyama K., Sawai, S., Mizutani M., Ohnishi T., Sudo H., Akashi T., Aoki T., Saito K., Muranaka T.: Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin, Proc. Natl. Acad. Sci. U S A. 2008, 105, 14204-14209.
Sekimata K., Ohnishi T., Mizutani M., Todoroki Y., Han SY., Uzawa J., Fujioka S.,Yoneyama K., Takeuchi Y., Takatsuto S., Sakata K., Yoshida S., Asami T.: Brz220 interacts with DWF4, a cytochrome P450 monooxygenase in brassinosteroid biosynthesis, and exerts biological activity, Biosci. Biotechnol. Biochem. 2008, 72, 7-12.
Ohnishi T., Szatmari AM., Watanabe B., Fujita S., Bancos S., Koncz C., Lafos M., Shibata K., Yokota T., Sakata K., Szekeres M., Mizutani M.: C-23 hydroxylation byArabidopsis CYP90C1 and CYP90D1 reveals a novel shortcut in brassinosteroid biosynthesis, Plant Cell 2006, 18, 3275-3288.
Ohnishi T., Watanabe B., Sakata K., Mizutani M.: CYP724B2 and CYP90B3 function in the early C-22 hydroxylation steps of brassinosteroid biosynthetic pathway in tomato, Biosci. Biotechnol. Biochem. 2006, 70, 2071-2080.
Ohnishi T., Nomura T., Watanabe B., Ohta D., Yokota T., Miyagawa H., Sakata K., Mizutani M.: Tomato cytochrome P450 CYP734A7 functions in brassinosteroidcatabolism, Phytochemistry 2006, 67, 1895-1906.
Fujita S.#, Ohnishi T.#, Watanabe B., Yokota T., Takatsuto S., Fujioka S., Yoshida S., Sakata K., Mizutani M.: Arabidopsis CYP90B1 catalyses the early C-22 hydroxylation of C27, C28 and C29 sterols, Plant J. 2006, 45, 765-774. (# equally contribution)
Sakamoto T., Morinaka Y., Ohnishi T., Sunohara H., Fujioka S., Ueguchi-Tanaka M., Mizutani M., Sakata K., Takatsuto S., Yoshida S., Tanaka H., Kitano H., Matsuoka M.: Erect leaves caused by brassinosteroid deficiency increase biomass production and grain yield in rice, Nature Biotechnol. 2006, 24, 105-109.