422-8529 静岡市駿河区大谷836   TEL/FAX 054-238-4871

TOP   |   研究内容(大西)  |   メンバー   |   発表論文(大西)  |   所属希望者へ   |   アクセス 

発表論文_轟 泰司


Google scholar citations
Takeuchi, J.; Ohnishi, T.; Okamoto, M.; Todoroki, Y.: The selectivity of 6-nor-ABA and 7 -nor-ABA for abscisic acid receptor subtypes, Bioorg. Med. Chem. Lett. 2015, in press.
Kamo, T.; Sakurai, S.; Yamanashi, T.; Todoroki, Y.: Cyanamide is biosynthesized from L-canavanine in plants, Sci. Rep. 2015, 5, 10527.
Takeuchi, J.; Ohnishi,T.; Okamoto, M.; Todoroki, Y.: Conformationally restricted 3'-modified ABA analogs for controlling ABA receptors, Org. Biomol. Chem. 2015, 13, 4278-4288.
Takeuchi, J.; Okamoto, M.; Akiyama, T.; Muto, T.; Yajima, S.; Sue, M.; Seo, M.; Kanno, Y.; Kamo, T.; Endo, A.; Nambara, E.; Hirai, N.; Ohnishi, T.; Cutler, S. R.; Todoroki, Y.: Designed abscisic acid analogues as antagonists of PYL-PP2C receptor interactions, Nat. Chem. Biol. 2014, 10, 477-482.
Murata, A.; Akaike, R.; Kawahashi, T.; Tsuchiya, R.; Takemoto, H.; Ohnishi, T.; Todoroki, Y.; Mase, N.; Yokoyama, M.; Takagi, K.; Winterhalter, P.; Watanabe, N.: Characterization of flower-inducing compound in Lemna paucicostata exposed to drought stress, Tetrahedron 2014, 70, 4969-4976.
Wang, J.; Yamada, Y.; Notake, A.; Todoroki, Y.; Tokumoto, T.; Dong, J.; Thomas, P.; Hirai, H.; Kawagishi, H.: Metabolism of bisphenol A by hyper lignin-degrading fungus Phanerochaete sordida YK-624 under non-ligninolytic condition, Chemosphere 2014, 109, 128-133.
Muto, T.; Todoroki, Y.: Brassinolide-2,3-acetonide: A brassinolide-induced rice lamina joint inclination antagonist, Bioorg. Med. Chem. 2013, 21, 4413-4419.
Baldermann, S.; Yang, Z.; Sakai, M.; Fleischmann, P.; Morita, A.; Todoroki, Y.; Watanabe, N.: Influence of exogenously applied abscisic acid on carotenoid content and water uptake in flowers of the tea plant Camellia sinensis, J. Sci. Food Agric. 2013, 93, 1660-1664.
Lechat, M.-M.; Pouvreau, J.-B.; Thoiron, S.; Peron, T.; Gauthier, M.; Montiel, G.; Veronesi, C.; Todoroki, Y.; Monteau, F.; Macherel, D.; Simier, P.; Delavault, P.: PrCYP707A1, an ABA catabolic gene, is a key component of Phelipanche ramosa seed germination in response to the strigolactone analog GR24, J. Exp. Bot. 2012, 63, 5311-5322.
Hirai, N.; Iwami, K.; Horiuchi, M.; Kano, K.; Todoroki, Y.; Ohigashi, H.: The electrolytic reduction of abscisic acid methyl ester and its free acid, Phytochemistry 2012, 80, 89-98.
Murata, A; Kai, K.; Tsutsui, K.; Takeuchi, J.; Todoroki, Y.; Furihata, K.; Yokoyama, M.; Baldermann, S.; Watanabe, N.: Enantio-selective reduction of the flowering related compound KODA and its analogues in Pharbitis nil cv. Violet, Tetrahedron 2012, 68, 5583-5589.
Okazaki, M.; Kittikorn, M.; Ueno, K.; Mizutani, M.; Hirai, N.; Kondo, S.; Ohnishi, T.; Todoroki, Y.: Abscinazole-E2B, a practical and selective inhibitor of ABA 8'-hydroxylase CYP707A, Bioorg. Med. Chem. 2012, 20, 3162-3172.
Todoroki, Y.; Naiki, K.; Muramatsu, T.; Ohnishi, T.; Ueno, K., Mizutani, M.; Hirai, N.: A conformationally restricted uniconazole analogue as a specific inhibitor of rice ent-kaurene oxidase, CYP701A6, Bioorg. Med. Chem. Lett. 2012, 22, 3240-3243.
Kondo, S.; Sugaya, S.; Sugawa, S.; Ninomiya, M.; Kittikorn, M.; Okawa, K.; Ohara, H.; Ueno, K.; Todoroki, Y.; Mizutani, M.; Hirai, N.: Dehydration tolerance in apple seedlings is affected by an inhibitor of ABA 8'-hydroxylase CYP707A, J. Plant Physiol. 2012, 169, 234-241.
Todoroki, Y.; Narita, K.; Muramatsu, T.; Shimomura, H.; Ohnishi, T.; Mizutani, M.; Ueno, K.; Hirai, N.: Synthesis and biological activity of amino acid conjugates of abscisic acid, Bioorg. Med. Chem. 2011, 19, 1743-1750.
Okazaki, M.; Nimitkeatkai, H.; Muramatsu, T.; Aoyama, H.; Ueno, K.; Mizutani, M.; Hirai, N.; Kondo, S.; Ohnishi, T.; Todoroki, Y.: Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8'-hydroxylase CYP707A, Bioorg. Med. Chem. 2011, 19, 406-413.
Todoroki, Y.; Ueno, K.: Development of specific inhibitors of CYP707A, a key enzyme in the catabolism of abscisic acid, Curr. Med. Chem. 2010, 17, 3230-3244.
Todoroki, Y.; Naiki, K.; Aoyama, H.; Shirakura, M.; Ueno, K., Mizutani, M.; Hirai, N.: Selectivity improvement of an azole inhibitor of CYP707A by replacing the monosubstituted azole with a disubstituted azole, Bioorg. Med. Chem. Lett. 2010, 20, 5506-5509.
Todoroki, Y.; Aoyama, H.; Hiramatsu, S.; Shirakura, M.; Nimitkeatkai, H.; Kondo, S.; Ueno, K.; Mizutani, M.; Hirai, N.: Enlarged analogues of uniconazole, new containing inhibitors of ABA 8'-hydroxylase CYP707A, Bioorg. Med. Chem. Lett. 2009, 19, 5782-5786.
Todoroki, Y.; Kobayashi, K.; Shirakura, M.; Aoyama, H.; Takatori, K.; Nimitkeatkai, H.; Jin, M.-H.; Hiramatsu, S.; Ueno, K.; Kondo, S.; Mizutani, M.; Hirai, N.: Abscinazole-F1, a conformationally restricted analogue of the plant growth retardant uniconazole and an inhibitor of ABA 8'-hydroxylase CYP707A with no growth-retardant effect, Bioorg. Med. Chem. 2009, 17, 6620-6630.
Todoroki, Y., Kobayashi, K., Yoneyama, H., Hiramatsu, S., Jin, M.-H., Watanabe, B., Mizutani, M., Hirai, N.: Structure-activity relationship of uniconazole, a potent inhibitor of ABA 8'-hydroxylase, with a focus on hydrophilic functional groups and conformation. Bioorg. Med. Chem. 2008, 16, 3141-3152.
Sekimata, K.; Ohnishi, T.; Mizutani, M.; Todoroki, Y.; Han, S.-Y.; Uzawa, J.; Fujioka, S.; Yoneyama, K.; Takeuchi, Y.; Takatsuto, S.; Sakata, K.; Yoshida, S.; and Asami, T. Brz220 interacts with DWF4, a cytochrome P450 monooxygenase in brassinosteroid biosynthesis, and exerts its biological activity. Biosci. Biotechnol. Biochem., 2008, 72, 7-12.
Shimomura, H.; Etoh, H.; Mizutani, M.; Hirai, N.; and Todoroki, Y.: Effect of the minor ABA metabolite 7'-hydroxy-ABA on Arabidopsis ABA 8'-hydroxylase CYP707A3. Bioorg. Med. Chem. Lett. 2007, 17, 4977-4981.
Ueno, K.; Yoneyama, H.; Mizutani, M.; Hirai, N.; and Todoroki, Y.: Asymmetrical ligand binding by abscisic acid 8'-hydroxylase. Bioorg. Med. Chem. 2007, 15, 6311-6322.
Saito, S., Okamoto, M., Shinoda, S., Kushiro, T., Koshiba, T., Kamiya, Y., Hirai, N., Todoroki, Y., Sakata, K., Nambara, E., and Mizutani, M.: A plant growth retardant, uniconazole, is a inhibitor of ABA catabolism in Arabidopsis. Biosci. Biotechnol. Biochem., 70, 1731-1739 (2006).
Mizutani, M. and Todoroki, Y.: ABA 8'-hydroxylase and its chemical inhibitors. Phytochem. Rev., 5, 385-404 (2006).
Araki, Y., Miyawaki, A., Miyashita, T., Mizutani, M., Hirai, N., and Todoroki, Y.: A new non-azole inhibitor of ABA 8'-hydroxylase: Effect of the hydroxyl group substituted for geminal methyl groups in the six-membered ring, Bioorg. Med. Chem. Lett., 16, 3302-3305 (2006).
Ueno, K., Yoneyama, H., Saito, S., Mizutani, M., Sakata, K., Hirai, N., and Todoroki, Y.: A lead compound for the development of ABA 8'-hydroxylase inhibitors, Bioorg. Med. Chem. Lett., 15, 5226-5229 (2005).
Ueno, K., Araki, Y., Hirai, N., Saito, S., Mizutani, M., Sakata, K., and Todoroki, Y.: Differences between the structural requirements for ABA 8'-hydroxylase inhibition and for ABA activity, Bioorg. Med. Chem., 13, 3359-3370 (2005).
Todoroki, Y., Sawada, M., Matsumoto, M., Tsukada, S., Ueno, K., Isaka, M., Owaki, M., and Hirai, N.: Metabolism of 5'a,8'-cycloabscisic acid, a highly potent and long-lasting abscisic acid analogue, in radish seedlings, Bioorg. Med. Chem., 12, 363-370 (2004).
Suzuki, M.,Yamaguchi, S.,Iida, T., Hashimoto, I., Teranishi, H., Mizoguchi, M., Yano, F., Todoroki, Y., Watanabe, N., and Yokoyama, M.: Endogenous a-ketol linolenic acid (KODA) levels in short day-induced cotyledons are closely related to flower induction in Pharbitis nil, Plant Cell Physiol., 44, 35-43 (2003).
Todoroki, Y., Hirai, N.: Abscisic acid analogs for probing the mechanism of abscisic acid reception and inactivation. In Studies in Natural Product Chemistry Volume 27: Bioactive Natural Products, Part H (Atta-ur-Rahman, ed.). Elsevier Science, Amsterdam (2002).
Todoroki, Y., Tanaka, T., Kisamori, M., and Hirai, N: 3'-Azidoabscisic acid as a photoaffinity reagent for abscisic acid binding proteins, Bioorg. Med. Chem. Lett., 11, 2381-2384 (2001).
Todoroki, Y. and Hirai, N: Conformational analysis of the cyclohexenone ring in abscisic acid and its analogs with a fused cyclopropyl ring, Tetrahedron, 56, 8095-8100 (2000).
Todoroki, Y., Hirai, N., and Ohigashi, H.: Analysis of isomerization process of 8'-hydroxyabscisic acid and its 3'-fluorinated analog in aqueous solutions, Tetrahedron, 56, 1649-1653 (2000).
Hirai, N., Okamoto, M., Fujimura, M., Ichiyama, T., Todoroki, Y., Ohigashi, H., Takeda, N., Yoshizumi, H., and Tatematsu, A.: Mechanism of formation of dehydrated ions from abscisic acid and its 1',4'-diol methyl esters in electron ionization mass spectrometry, J. Mass Spectrom. Soc. Jpn., 48, 8-22 (2000).
Hirai, N., Yoshida, R., Todoroki, Y., and Ohigashi, H.: Biosynthesis of abscisic acid by the non-mevalonate pathway in plants, and by the mevalonate pathway in funji, Biosci. Biotechnol. Biochem., 64, 1448-1458 (2000).
Arai, S., Todoroki, Y., Ibaraki, S., Naoe, Y., Hirai, N., Ohigashi, H.: Synthesis and biological activity of 3'-chloro, -bromo, and -iodoabscisic acids, and biological activity of 3'-fluoro-8'-hydroxyabscisic acid, Phytochemistry, 52, 1185-1193 (1999).
Kashem, M.A., Hori, H., Itoh, K., Hayakawa, T., Todoroki, Y., Hirai, N., Kurimura, Y., Ohigashi, H., Mitsui, T.: Effect of (+)-8',8',8'-trifluoroabscisic acid on α-amylase expression and sugar accumulation in rice cells, Planta, 205, 319-326 (1998).
Kobayashi, M., Todoroki, Y. ,Hirai, N., Kurimura, Y., Ohigashi, H., Tsuji, Y.: Biological activities of abscisic acid analogs in the morphological change of the green alga Haematococcus pluvialis, J. Ferment. Bioeng., 85, 529-531 (1998).
Todoroki, Y., Nakano, S., Arai, S., Hirai, N., and Ohigashi, H.: Synthesis and biological activities of 8'-methylene- and 8'-methylidyneabscisic acids, Biosci. Biotechnol. Biochem., 61, 2043-2045 (1997).
Todoroki, Y., Nakano, S., Hirai, N., Mitsui, T., and Ohigashi, H.: Synthesis, biological activity, and metabolism of 8',8',8'-trideuteroabscisic acid, Biosci. Biotechnol. Biochem., 61, 1872-1876 (1997).
Todoroki, Y., Nakano, S., Hirai, N., Ohigashi, H.: Ring conformational requirement for biological activity of abscisic acid probed by the cyclopropane analogues, Tetrahedron, 52, 8081-8098 (1996).
Nakano, S., Todoroki, Y., Hirai, N., Ohigashi, H.: Synthesis and biological activity of 7'-, 8'-, 9'-alkyl analogues of abscisic acid, Biosci. Biotechnol. Biochem., 59, 1699-1706 (1995).
Todoroki, Y., Hirai, N., Ohigashi, H.: Synthesis, biological activity and metabolism of (S)-(+)- 3'-fluoroabscisic acid, Tetrahedron, 51, 6911-6926 (1995).
Todoroki, Y., Hirai, N., Ohigashi, H.: Syntheis and biological activity of 1'-deoxy-1'-fluoro- and 8'-fluoroabscisic acid, Phytochemistry, 40, 633-641 (1995).
Todoroki, Y., Hirai, N., Koshimizu, K.: 8',8'-Difluoro- and 8',8',8'-trifluoroabscisic acids as highly potent, long-lasting analogues of abscisic acid, Phytochemistry, 38, 561-568 (1995).
轟 泰司, 平井伸博:植物のストレスメッセンジャー・アブシジン酸の現在, 化学と生物, 33, 122-130 (1995).
Todoroki, Y., Hirai, N., Koshimizu, K.: 8'- and 9'-Methoxyabscisic acids as antimetabolic analogs of abscisic acid, Biosci. Biotechnol. Biochem., 58, 707-715 (1994).