Reserch ProjectPublicationsトMembersActivities Report

Original Paper (~2000)

2000

61 H. Uehara, D. B. Choi, Yongsoo Park, and M. Okabe, Expression of mouse a-amyalse gene in methylotrophic yeast Pichia pastoris, Biotechnology and Bioprocess Engineering, 5 (1), 7-12 (2000). 
60 D. B. Choi, Enoch Y. Park, and M. Okabe, Dependence of apparent viscosity on morphology of Streptomyces fradiae in various nitrogen source, Biotechnol. Prog., 16 (4), 525-532 (2000).

1999

59 Yongsoo Park, Ueda, T., Hitaka, T., Kano, A., and M. Okabe, Protoplast isolation and preliminary culture of Doritaenopsis, Bull. Fac. Agric. Shizuoka Univ., 49, 1-7, (1999).
58 Yongsoo Park, M. Ichida, Y. Kosakai, M. Okabe, Kinetics of soybean oil consumption and cephamycin C production in culture of Streptomyces sp. using mineral support, J. of Biosci. Bioeng., 87(3), 390-393 (1999).
57  Higashiyama, K., S. Fujikawa, Yongsoo Park, and M. Okabe, Image analysis of morphological change during AA production by M. alpina 1S-4, J. of Biosci. Bioeng., 87(4), 489-494 (1999).
56 Yongsoo Park, T. Saito, T. Dojima, M. Horiba, M. Toriyama, and M. Okabe, Visualization of a recombinant gene protein in the baculovirus expression vector system using confocal scanning laser microscope, J. of Biosci. Bioeng., 87(6), 756-761 (1999).
55 Yongsoo Park, Y. Koike, S. Fujikawa, and M. Okabe, Effect of nitrogen source on mycelial morphology and arachidonic acid production in cultures of Mortierella alpina, J. of Biosci. Bioeng., 88(1), 55-61 (1999).
54  H. Hanyu, Yongsoo Park, M. Okabe, S. Billings, G. Jelenkovic, H. Pedersen, C.-K. Chin, Expression of luciferase gene in eggplant through Agrobacterium-mediated genetic transfromation, Plant Biotechnol., 16 (5), 403-407 (1999).

1998

53 Choi, D. B., Yongsoo Park, and M. Okabe, Effect of rapeseed oil on activity of methylmalonyl-CoA carboxyltransferase in cuture of Streptomyces fradiae, Bioscience, Biotechnol. Biochem. 62(5), 902-906, (1998).
52 Yin, P., Yahiro, K., Ishigaki, T., Yongsoo Park, Okabe, M., L(+)-Lactic acid production by repeated batch culture of Rhizopus oryzae in air-lift bioreactor, J. Ferment. Bioeng., 85(1), 96-100 (1998).
51 Choi, D.B., Yongsoo Park, M. Okabe, Improvement of tylosin production from Streptomyces fradiae cultute by decrease in apparent viscosity in an air-lift bioreactor, J. Ferment. Bioeng., 86(4), 413-417 (1998).
50 Yongsoo Park, Y. Kosakai, M. Okabe, Efficient production of L(+)-lactic acid using mycelial cotton like flocs of Rhizopus oryzae in air-lift bioreactor, Biotechnol. Progress, 14, 699-704, (1998).

1997

49 Yongsoo Park, Uehara, H., Terura, R., and M. Okabe, Effect of culture temperature and dissolved oxygen concentration on expression of a-amylase gene in batch culture of spore-forming host, Bacillus subtilis 1A289, J. Ferment. Bioeng., 84 (1), 53-58 (1997).
48 Yin, P., Nishina, N., Kosakai, Y., Yahiro, K., Yongsoo Park, and M. Okabe, Enhanced production of L(+)-lactic acid from corn starch in culture of Rhizopus oryzae using air-lift bioreactor, J. Ferment. Bioeng., 84 (3), 249-253 (1997).
47 Yahiro, K., Shibata, S., J, S., Yongsoo Park, and M. Okabe, Enhanced production of itaconic acid from raw corn starch, J. Ferment. Bioeng., 84(4), 375-377 (1997).
46 Yahiro, K., Takahama, T., Jia, S., Yongsoo Park, and M. Okabe, Comparison of air-lift bioreactor and stirred tank reactors for itaconic acid production by Aspergillus terreus TN-484, Biotechnol. Lett., 19(7), 619-621 (1997).
45 Yongsoo Park, Tamura, S., Toriyama, M., and M. Okabe, Mycelial pellet intrastructure visualization and viability prediction in a culture of Streptomyces fradiae using confocal laser scanning microscopy, J. Ferment. Bioeng., 84(5), 483-486 (1997).
44 Michuru Ichida, Yongsoo Park, Yuko Kosakai and Mitsuyasu Okabe, Application of mineral support on cephamycin C in culture using soybean oil as the sole carbon source, Biotechnol. Bioeng., 53, 207-213 (1997).
43 Kishimoto, K, Yongsoo Park, M. Okabe, and S. Akiyama, Effect of ferrous ion on amino acid metabolism in mildiomycin production by Streptoverticillium rimofaciens, J. Antibiotics, 50(3), 206-211 (1997).
42 Y. Kosakai, Yongsoo Park, and M. Okabe, Enhancement of L(+)-lactic acid production using mycelial flocs of Rhizopus oryzae, Biotechnol. Bioeng., 55(3), 461-470 (1997).
41 Hwang, G., Okamoto, R., Hikita, A., Yongsoo Park, and M. Okabe, Optimization of bioconversion of tylosin to a novel antibiotics acetyl-isovaleryl tylosin (AIV) by Streptomyces thermotolerans and scale-up to 200 liters pilot scale fermentor, J. Ferment. Bioeng., 84(1), 77-81 (1997).
40 Tamura, S., Yongsoo Park, Toriyama, M., and M. Okabe, Change of mycelial morphology in tylosin production by batch culture of Streptomyces thermotolerans with various shear conditions, J. Ferment. Bioeng., 83(6), 523-528 (1997).
39 Jia, S., Wang, M., Kahar, P., Yongsoo Park, and M. Okabe, Enhancement of yeast fermentation by addition of oxygen-vectors in air-lift bioreactor, J. Ferment. Bioeng., 84(2), 176-178 (1997).

1996

38 Yongsoo Park, T. Dojima, and Mitsuyasu Okabe, Enhanced a-amylase production in a recombinant Bacillus brevis by fed-batch culture with amino acid control, Biotechnol. Bioeng., 49, 36-44 (1996).
37 Yongsoo Park, S. Kakuta, A. Kano, and M. Okabe, Efficient propagation of protocorm like bodies of Phalaenopsis in liquid medium, Plant, cell, tissue & organ culture, 45 (1), 79-85 (1996).
36 Kishimoto, Yongsoo Park, and M. Okabe, Effect of ferrous ion on mildiomycin production by Streptoverticillium rimofaciens, J. Antibiotics, 49 (8), 770-774 (1996).
35 Kishimoto, Yongsoo Park, and M. Okabe, Effect of phosphate ion on mildiomycin production by Streptoverticillium rimofaciens, J. Antibiotics, 49 (8), 775 780 (1996).
34 Jia, S., Li, P., Yongsoo Park, and M. Okabe, Enhanced oxygen transfer in tower bioreactor by addition of the liquid hydrocarbon, J. Ferment. Bioeng. 82, 191-193 (1996).
33 B. Choi, S. Tamura, Yongsoo Park, M. Okabe, Y. Seriu, S. Takeda, Efficient tylosin production from Streptomyces fradiae unsing rapeseed oil, J. Ferment. Bioeng. 82(2), 183-186 (1996).

1995

32 Noriyasu Ohta, Yongsoo Park, Kazutoyo Yahiro, and Mitsuyasu Okabe, Comparison of neomycin production from Streptomyces fradiae cultivation using soybean oil as the sole carbon source in an air-lift bioreactor and a stirred-tank reactor, J. Ferment. Bioeng., 79 (5), 443-448 (1995).
31 Kazutoyo Yahiro, Tetsushi Takahama, Yongsoo Park, and Mitsuyasu Okabe, Breeding of Aspergillus terreus mutant TN-484 for itaconic acid production with high yield, J. Ferment. Bioeng., 79 (5), 506-508 (1995).

1994

30 Mitsuyasu Okabe, Atsusi Oda, Yongsoo Park, Katsuhiro Noguchi, Takanori Okamoto, Shunsuke Mitsui, Continuous beer fermentation by high cell-density culture of bottom brewer's yeast, J. Ferment. Bioeng., 77(1), 41-45 (1994).
29 Hideo Kurokawa, Yongsoo Park, Shinji Iijima, Takeshi Kobayashi, Growth characteristics in fed-batch culture of hybridoma with control of glucose and glutamine, Biotechnol. and Bioeng., 44(1), 95-103 (1994).
28 Yongsoo Park, Isao Momose, Kimiko Tsunoda, Mitsuyasu Okabe, Enhancement of cephamycin C production using soybean oil as the only carbon source, Appl. Microbiol. Biotechnol., 40(6), 773-775 (1994).
27 Yongsoo Park, Mitsuru Ichida, Noriyasu Ohta and Mitsuyasu Okabe, Itaconic acid production using air-lift bioreactor in repeated batch culture of Aspergillus terreus, J. Ferment. Bioeng., 77(3) (1994).
26 Tsujimura, M. takaya, K. Katano, N. Matsumoto, Yongsoo Park, Mitsuyasu Okabe, Scale-up of peroxidase production by Anthromyces ramosus based on analysis of fluid distribution, J. Ferment. Bioeng., 77(6), 650-654 (1994).
25 Sumihisa Shiba, Yongsoo Park, Shinji Iijima, and Takeshi Kobayashi, Y. Nishida, Improvement of cloned gene expression in fed-batch culture of recombinant S. cerevisiae with controlling concentrations of both glucose and ethanol by fuzzy controller, Biotechnol. Bioeng., 44, 1055-1063 (1994).
24 Yongsoo Park, Kouji Inoue, Kazutoyo Yahiro and Mitsuyasu Okabe, Improvement of cephamycin C production by mutant strain resistant to linoleic acid, J. Ferment. Bioeng., 78(1), 88-92 (1994).
23 Hideo Tsujimura, Masamitsu Takaya, Kenji Katano, Nobuya Matsumoto, Yongsoo Park and Mitsuyasu Okabe, Peroxidase production by carbon-nitrogen sources fed-batch culture of Arthromyces ramosus, Biotechnol. Lett., 16(6), 575-580 (1994).
22 Yongsoo Park, Noriyasu Ohta, Mitsuyasu Okabe, Neomycin production by partial immobilized Streptomyces fradiae on cellulose beads in an air-lift bioreactor, J. Ferment. Biotechnol., 78 (3), 265-268 (1994).
21 Wang, N. Hata, Y. S. Park, S. Iijima, T. Kobayashi, Effect of dissolved oxygen concentration on anchorage-dependent cell growth and erythropoietin production, J. Ferment. Bioeng., 78(4), 321-326 (1994).

1993

20 Yongsoo Park, Zhong Ping Shi, Sumihisa Shiba, Cayuela Chantal, Shinji Iijima, and Takeshi Kobayashi, Application of fuzzy reasoning on control of glucose and ethanol concentrations in baker's yeast culture, Applied Microbiology and Biotechnology, 38: 649-655 (1993).
19 Yongsoo Park, Sumihisa Shiba, Shinji Iijima, and Takeshi Kobayashi, Comparison of secretory a-amylase productions in fed-batch cultures of recombinant Saccharomyces cerevisiae harboring three different promoters, Biotechnol. and Bioeng., 41, 854-861 (1993).
18 Chantal Cayuela, Kenichi Kai, Yongsoo Park, Shinji Iijima, Takeshi Kobayashi, Insecticide production by recombinant Bacillus subtilis 1A96 in fed-batch culture with control of glucose concentration, J. Ferment. Bioeng., 75(5), 383-386 (1993).
17 Mituyasu Okabe, Noriyasu Ohta, Yongsoo Park, Itaconic Acid Production in Air lift Bioreactor using Modified Draft Tube, J. Ferment. Bioeng., 76(2), 117-122 (1993).
16 Yongsoo Park, Noriyasu Ohta and Mitsuyasu Okabe, Effect of dissolved oxygen concentration and impeller tip speed on itaconic acid production by Aspergillus terreus, Biotechnology Lett., 15(6), 583-586 (1993).
15 Hideo Kurokawa, Tatsuya Ogawa, Masamichi Kamihira, Yongsoo Park, Shinji Iijima, Takeshi Kobayashi, Kinetic study of hybridoma metabolism and antibody production in continuous culture using serum-free medium, J. Ferment. Bioeng., 76(2), 128-132 (1993).

1992

14 Yongsoo Park, Kenichi Kai, Shinji Iijima, and Takeshi Kobayashi, Enhancement of b-galactosidase production by high cell-density culture of recombinant Bacillus subtilis with the control of glucose concentration. Biotechnol. and Bioeng., 40, 686-696 (1992).
13 Yongsoo Park and Kiyoshi Toda, Multi-stage shallow flow bioreactor for acetic acid production at high concentration. Biotechnology letters, 14 (7), 609-612 (1992).
12 Masai Fukaya, Yongsoo Park, and Kiyoshi Toda, Improvement of acetic acid fermentation by molecular breeding and process development, Journal of Applied Bacteriology, 73, 447-454 (1992).

1991

11 Yongsoo Park and Kiyoshi Toda, Production of high concentration acetic acid by a repeated fed-batch culture with cell recycle of Acetobacter aceti, Applied Microbiology and Biotechnology, 35(2), 149-153 (1991).
10 Yongsoo Park, Masahiro Fukaya, Yoshiya Kawamura, and Kiyoshi Toda, Production of acetic acid by a repeated batch culture with cell recycle of Acetobacter aceti, Biotechnology Letters, 13(4), 271-276 (1991).
9 Kenichi Kai, Yongsoo Park, Shinji Iijima, and Takeshi Kobayashi, High concentration culture of Bacillus subtilis spo- mutant strain carrying a recombinant plasmid. J. Ferment. Bioeng., 73(3), 248-250 (1991).

1990

8 Yongsoo Park and Kiyoshi Toda, Simulation study on bleed effect in cell-recycle culture of Acetobacter aceti, Journal of General and Applied Microbiology, 36(4), 221 233 (1990).
7 Yongsoo Park, Hisao Ohtake, and Kiyoshi Toda, A kinetic study on acetic acid production by liquid-surface culture of Acetobacter aceti, Applied Microbiology and Biotechnology, 33(3), 259-263 (1990).
6 Yongsoo Park and Kiyoshi Toda, Effect of tricarboxylic acid intermediates on acetic acid production by Acetobacter aceti, Journal of General and Applied Microbiology, 36, 105-110 (1990).

1989

5 Yongsoo Park, Hisao Ohtake, Kiyoshi Toda, Masahiro Fukaya, Hajime Okumura, and Yoshiya Kawamura, Acetic acid production using a fermentor equipped with a hollow fiber filter module, Biotechnol. and Bioeng., 33(7), 918-923 (1989).
4 Yongsoo Park, Hisao Ohtake, Masahiro Fukaya, Yoshiya Kawamura, and Kiyoshi Toda, Effects of dissolved oxygen and acetic acid concentration on acetic acid production in continuous culture of Acetobacter aceti, J. Ferment. and Bioeng., 68(2), 96-101 (1989).
3 Yongsoo Park, Hisao Ohtake, Masahiro Fukaya, Yoshiya Kawamura, and Kiyoshi Toda, Enhancement of acetic acid production in a high cell-density culture of Acetobacter aceti, J. Ferment. and Bioeng., 68(5), 315-319 (1989).
2 Kiyoshi Toda, Yongsoo Park, Tomoko Asakura, Chu Yuan Cheng, and Hisao Ohtake, High-rate of acetic acid production in shallow flow bioreactor, Applied Microbiology and Biotechnology, 30(6), 559-563 (1989).

1983

1 In Jae Chung and Yongsoo Park, Ethanol fermentation by Saccharomyces cerevisiae in a bioreactor packed vertically with ceramic rod, Journal of the Korean Institute of Chemical Engineers, 21 (3) 151-158 (1983).

Laboratory of Biotechnology.
Green Chemistry Research Division, Research Institute of Green Science and Technology